Purpose: The aim of this study was to investigate the relationship between self-differentiation and marital boredom of female teachers. Method: This is a descriptive correlational study and the statistical population of the present study included Married Women Teachers in District 7 Mashhad  in 2017-18. The sample size in this study was 260 people who were selected simple Multi-step randomization. To collect data, three questionnaires were used: a) Paniz's Marital disturbance (1986), b) Self-differentiation questionnaire DSI-R (1998). To analyze the data, descriptive statistics (mean, standard deviation) and inferential statistics, Pearson correlation analysis were used and statistically analyzed by SPSS software. Results: The results showed that there is a significant negative correlation between self-differentiation and marital boredom of 38 degrees.