Objective: The purpose of this study was to compare resilience and perceived stress in specialist and non-specialist paramedics in Semnan. Method: The method of the present study is applied in terms of purpose and in terms of how to collect information, it is comparative causal research. The statistical population of this study is all specialized and non-specialized aid workers in Semnan in 2016-2017, whose statistical population was 420 people. Using Cochran's formula, 200 people were selected using stratified random sampling method. There were 105 specialist helpers and 95 non-specialist helpers. Data collection tools were the standard Resilience Scale Questionnaire and the Perceived Stress Questionnaire (PSS), which were used to test the hypotheses by the Human Whitney and Spearman tests. Finding: Perceived stress is significant among specialized and non-specialized aid workers and the perceived stress of specialized aid workers is less than non-specialized aid workers of Semnan Red Crescent. And the difference between resilience between specialized and non-specialized aid workers is significant, ie the resilience of specialized aid workers is more than non-specialist aid workers of Semnan Red Crescent. Conclusion: The results showed that there is an inverse and indirect relationship between the two variables of resilience and perceived stress.