The aim of this study was to investigate the relationship between psychological well-being and social adjustment with emotional intelligence of mothers with children with autism in Tabriz. The present study is based on the purpose of the applied type and on the method of collecting research data of the correlation type. The statistical population of the study included 200 mothers with children with autism in Tabriz, of which 127 were selected using Morgan table and stratified random sampling. The research instruments included Riff Psychological Well-Being Questionnaire (1989), Piquel and Wiseman (1999) Social Adjustment Questionnaire and Bar-On (1980) Emotional Intelligence Questionnaire. SPSS23 was used to analyze the data and Pearson correlation and multiple regression methods were used to answer the research hypotheses. According to the results of the study, there is a relationship between emotional intelligence and social adjustment of mothers with children with autism in Tabriz (r <0.711, P <0.001), there is a relationship between emotional intelligence and psychological well-being (P <0.001, = 850 / 0r). The results of the present study indicate the importance of emotional intelligence as one of the important components of psychology. Therefore, providing training based on strengthening emotional intelligence and social adjustment and psychological well-being leads to their better social performance.