Major depressive disorder is one of the most important and common psychiatric disorders that has extensive individual, social, and economic consequences. Numerous studies have emphasized the effectiveness of psychological treatments in reducing depressive symptoms. Two prominent approaches in this field are cognitive-behavioral therapy and acceptance and commitment therapy. The aim of the present study was to compare the effectiveness of these two approaches on depressive symptoms, irrational thoughts, emotional inhibition, and value in the lives of patients with major depressive disorder. The research method was a quasi-experimental type with a pretest-posttest design and a control group. The statistical population included all patients with major depression referring to psychology and psychiatry centers in Tehran in 1404. Among them, 45 people were selected through purposive sampling and randomly assigned to three groups (cognitive behavioral therapy, acceptance and commitment therapy, and control). The research instruments included Beck Depression Inventory-II, Jones Irrational Thought Scale, King et al. Emotional Inhibition Questionnaire, and Wilson et al. Value in Life Questionnaire. Data were analyzed using multivariate analysis of covariance. The results showed that both cognitive behavioral therapy and acceptance and commitment therapy were effective in reducing depressive symptoms (p<0.008, F=23.64), irrational thoughts (p<0.025, F=23.02, 0.09), emotional inhibition (p<0.037, F=42.83), and increasing value in life (p<0.05). Comparison of means showed that acceptance and commitment therapy was superior in increasing self-esteem and reducing emotional inhibition, while cognitive behavioral therapy was more effective in reducing irrational thoughts. Based on the findings of this study, it can be concluded that the choice of treatment approach should be based on the specific needs of depressed patients.
                     
                    
                    
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Special  Received: 2025/07/23 | Revised: 2025/08/30 | Accepted: 2025/08/19 | Published: 2025/09/1